As someone who has extensively played this game, I just wanted to comment on this. I didn't experience any of these specific issues (and I use two monitors). That does not mean I did not experience other issues. You had to use the DX9c render for AMD cards at some point (a Unity update broke that). The game suffers from crashes during exit if you load too much custom content. It doesn't like repeated returns to the main menu. Otherwise it runs completely stable, and I haven't seen any savegame corruption yet that some people mention (probably an autosave bug).
Regarding your memory issue, this is, from my (and from other's who tested this) experience, completely false. The game runs a 400k person city with about 3.7 GB memory usage. This rises quickly with custom content you use. When I had 920 different custom assets (many of them poorly optimized) and two dozen mods, the game grasped all it could get on my system (12.7 GB RAM). This means, RAM usage depends purely on custom content use, and the limit how much you can use depends on your system. The base game without custom content stays strictly within the official minimum specs, which means below 4 GB. As with all simulations, the true limit is CPU power.