Ugh I can't decide what family to join in Reno. I mean the Wrights seem to be less evil than the rest but I am not sure about that in the long run. Decisions decisions...
Do you get some warning when killing important NPC characters, kind of like in Morrowind? I was tempted to shoot the gun dealer in Reno and loot him but I thought he might be useful later, especially since he did not have anything special when I visited him.
Wrights are selling booze and have some lowlifes or perhaps slaves working in distillery. So they aren't that nice as the game tries to suggest. Alcohol is a drug too, no? So I usually try to cheat on all of them, and let Wrights gain control of New Reno without SAD weapons while avoiding end-overriding contition of sleeping with Leslie Ann/Angela without condoms. That's the best you can get for Biggest Small City.
I usually do this:
Bishops: Easiest one. Get briefcase from preacher in Vault City. Speak with the guard on the second floor and tell him you have package for Mr. Bishop. On your way to him, sleep with Angela while having condoms of your choice, then rob the place without touching Bishop's safe. Deliver the briefcase to Bishop and get first job to murder Roger Westin. Go to him and get counter-proposal. Accept and go sleep with Bishop's wife while pumped up with mentats and buffout while having condoms of your choice to squeze her out of all useful information (you can suggest that she should assassinate him but I never got that one working, get speech-improving module, all the details about family etc. You can become Pornstar to have easier time as she will fall asleep if you performed weak). As you are done with her, open up her safe with the code she mutters while sleeping then proceed to disarm the trap and open Bishop's safe. Get all goodies, rearm the trap, use Repair skill, tell Bishop that you are still on the job. Wait on the second floor for the explosion. Return to Westin for reward.
Wrights: Do Mrs. Wright quest before becoming Pornstar or otherwise she won't talk to you unless doing first quest for Mr. Wright. Remember to not blow up distillery before you are done with Mr. Wright or otherwise he may turn hostile while speaking with him. Get the first quest and say Salvadore's are responsible after completing invastigation. Get the second quest, proceed to SAD. After you are done there, make sure you have or Myron has 130% science skill. Use the robot to get virus vial and contaminate whole base, then get the best brain for robot companion. Return to Wright and say that he won't get his weapons. Leave him alive.
Mordinos: Refer to Big Jesus as Senor Mordino at all times. Get the quest to assassinate Salvadore.
Salvadores: Refer to Louis Salvadore as Mr. Salvadore, be nice to Mason. Get the quest with desert transaction. If you were respectful towards them then Salvadore will give you laser pistol and Mason will teach you how to use it. Go peep the place out and return for your rewards (if you have high charisma and *maybe*, bacause I'm not sure, if you were respectful towards them, these rewards will be better). Go check up on Miss Kitty and Elridge because afterwards you won't have Made Man title. Now steal the gas tank from Salvadore for xp then exterminate whole casino on your way out.
Mordinos: Return to Big Jesus Mordino and remain respectful towards him. Politely decline membership and he will let you go without a fight. Use Jet on him on your way out. If you want Lil' Jesus Combat Knife then you have to kill them all or use Superstims or place bunch of C4 in his pockets while going to world map.
That's how I roll. That's how you milk all those scum from their money and experience and how you get probably the best ending for the place.
And no. There is no warning. If you start fight in Arroyo then it is game over otherwise you can kill anyone and still beat the game.