Really all you need to do is pick which Speech skill you want to use and which Combat skill you want to use and that's about it since you will be getting the most out of those two skills more than any other apart from Hacking/Security. Then just pick one or two of the disciplines that you think sounds fun to use and you're all good.
My personal favourite type of chracter to play is Tremere with ranged, persuasion and thaumatology. It has a nice "gimmick fps" feel to it causing bodies to explode everywhere while mowing down anyone that gets in your way.
My personal favourite type of chracter to play is Tremere with ranged, persuasion and thaumatology. It has a nice "gimmick fps" feel to it causing bodies to explode everywhere while mowing down anyone that gets in your way.