ASFV? I'm assuming Pinky on A, Ring on S, Index on FV? You don't need Dex to press a key fast or to hold it down, you need Dex to reach far keys. While running forward with your index finger on F you then only have your middle finger available for alternate key presses, which leaves open only E/D/C/R/X as usable controls. There is no second finger available to move forward/backward that would leave the index finger available to utilize its dexterity.
The advantage of WASD or similar schemes is that you can smoothly press 10-20 keys easily without affecting movement. All 4 directions and all 8 directional combinations can be easily done with multiple sets of fingers, leaving the entire side of the keyboard free for mapping of controls. If I need to hit Y/J/N with ESDF, I can quickly switch ring finger to E and middle finger to D, then reach half way across the keyboard. If I need to hit C, I can either use index + middle or ring + middle to hold down whatever key I need while the other key gets C.
Here's an exercise for you Christoffer. Swivel your chair away from your monitor with your hands down by your side, now look back directly at your monitor and press Ctrl+Alt+R without looking at the keyboard. You either missed the right keys or you hesitated to make sure you were on the right keys.
I thought anyone who knew how to keyboard could do this? CTRL/ALT/SHIFT combinations should be completely ingrained in the memory of anyone who uses shortcuts for things.