I've played for quite a bit on normal and I couldn't get very far, so I switched to easy. I don't consider myself to be very bad at games like this, but I find this harder than Battle Brothers that I usually play on Expert. I know that game a lot better so you know...
I've reached the last boss today and couldn't beat them, I think I'm underleveled with most of my guys being lower than lvl 25. I'll have to grind around a bit. Anyway, a few observations:
1. The game gets really grindy, even more so than Battle Brothers which is the game I mostly compare it to.
2. I had no one turn into a vampire or werebeast yet, but judging from the post above I'd like them to gain some bonuses and maluses that you would associate with them. For example, life leech, but maybe a special malus concerning damage type or something. If they straight up turn into the vampire monsters we're fighting I would say that this is not the best way to go.
3. Trilium, money - I wish I could do more with it? Maybe a fixed limit on buying maybe 100 alcohol per map somewhere, an unlocked merchant that you can find after a fight?
4. Flesh and blood, as far as I understand, only serve the purpose of making medicine and healing infections (?). I had no infections but I have far too much of the stuff.
5. Concerning medicine, I wish I could spend more medicine to speed up the healing process, get an even to do so (except Urtuk's mutations).
6. The world and setting are really cool and I like it very much.
7. I'm playing on the easiest difficulty and the Bounty hunters turning up with 30 guys against your six is barely beatable when exploiting the terrain. I can't imagine how it is on bigger difficulties, maybe allow 2 temporary slots when defending a village or stronghold.
8. The game might have told me that, but if it did it's far too easy to miss, for example, I figured out that I can stack mutators very late. Creating medicine wasn't very obvious either. This one might be on me mostly.
9. I see that faction interaction is planned, I wish I could pay off bounty hunters, hire mercs to maybe attack a place for me so I can follow up, ect.
Anyway, I still think it's a great game. I'm interested in the new starts that I should unlock once I beat the game.