This might go without saying, but high Intelligence and Charisma (with Persuasion) are required to get all the best dialogues in the game. If you want to get the most out of the story and characters on your first play-through, I'd suggest you put some focus on those stats. Also, mastery in Persuasion allows you to have any character join your party despite their good/evil alignment. However, any required Tech/Magick alignment will not be ignored.
Going Magick is definitely the easiest route to go down. There's a helpful
spell guide online to help you choose the best spells. Technology isn't utterly intuitive, but it's interesting. In my current game, I'm creating a charismatic technologist with the Miracle Operation background. I lose some Strength, Constitution and Dexterity, but get a lot of Perception (for Firearms), Intelligence (for inventing) and Charisma (for Persuasion) and will counteract my low Dexterity (max. 17) with charged rings.
Throwing is the best combat skill in the game. You'll get weapons with incredible range, decent speed and damage and which won't get destroyed when used against golems/elementals, doors or containers. Not only that, but the best weapons in the game are both throwing weapons: Azram's Star (found at K'na T'ha during the mastery quest) and the Aerial Decapitator (which is an easter egg you'll have to look up to find). Backstab and Prowling with training is also an incredible combination.
You might also want to get the Worthless Mutt, who is the best melee fighter in the game (partly because as a creature he gets master training to all skills automatically) and doesn't take up a character slot. You'll have to rush to the town of Ashbury to get him. I think after two weeks he dies, so just spend only a day or two in Shrouded Hills, walk to Tarant and then immediately take the train to Ashbury. You'll find him next to the local inn. The one consequence to having him in your party is you can't take any fast transportation, so you'll have to walk everywhere. To counteract this, he's best used with a magick character who with at least 18 Willpower and 5 character points invested into the magick school of Conveyance can teleport to any known location. If you go tech or want even more protection as a mage, just get Sogg (found at the inn in Shrouded Hills, 9 Charisma is needed).
As others have said, play in turn-based or fast turn-based. Real-time gets way too chaotic.
Getting your preferred stats to the maximum value of 20 is not required to master your skills, but is encouraged for unique benefits.
20 Strength = Double damage bonus
20 Dexterity = 25 speed (+1 point for every point over 20)
20 Constitution = Immunity to poison
20 Beauty = +100% reaction modifier
20 Intelligence = +10% success rate to all skills
20 Perception = Sense invisible
20 Willpower = Any spell resisted by Willpower gains you immunity
20 Charisma = 100% loyalty: followers never flee from your side and will not leave unless asked
Lastly, here's some control stuff a lot people miss:
Party commands - For use with a specific characters you can type their name prior to the command (i.e. "virgil attack"); for use with all party members type # before the command.
walk (order all with F1)
attack (order all with F2)
close (order all with F3)
spread (order all with F4)
back off (order all with F5)
leave
wait
come
Called shots - Hold the corresponding keys while attacking.
, = head
. = arms
/ = legs