With that interview and my crystal ball i can already foresee what that game will be like...
You will select your characters amongst various archetypes, warrior, cleric, mage, warlock... err no wrong clone it will be melee type character , maybe savage tribe type, then instead of a mage youll get a gun centric character, no cleric off course but a doc, also no warlock but a tech class with droid pets(mr handy ?). The interface will be very similar to wow and you will use hotbars with abilities like power slam for melee, headshot for gunner etc...
You will gain level after level, lets say 50 levels by accepting random quests from npc with big question marks over their heads in successive quest hubs.
Kill 20rats type quests for early levels , kill 20 rad scorpions type quest for mid levels+ instances(raider camp,vault etc) and for high levels kill 20 supermutants.
They also plan an amazing quest to get your mount in this case : a cadillac.
No death at all, period! cause nowadays death is uncool , if the average joe dont feel he has accomplished something after his game session its a bad game, so instead we will have player defeat, wich means you will get up after 10 sec and get a whopping temporary 10% malus on your stats
Most of the content is soloable off course cause anything promoting player interactivity is bannable , except the mandatory end game raids, this time you will raid enclave guys or some master clone type with 15 other guys (cause more than 15 is not manageable for todays players)
Childrens beware!!! this game is rated mature 18+.. by USA standard, wich means theres maybe the hint oft he shadow of some pixelated tits!!!and lot of gratuitous gore.
It will be released full of the bugs, rushed unoptimized , sell around 500k units and the endgame content will be missing, but some will love it for what it is, alas it will only last a few months and be put on life support aka warhammer online.
Quote me in a year or two it will be exactly like this. Come on, they are not making an eve online in the wastelands, with deep and complex player interaction, they would already tell it.
Ill put my hand in the fire and back it up with photos on the codex if it turns out different.