As far as mods and patches go, you could get the unofficial 1.8 patch. It fixes some bugs, but also makes some big changes here and there. Aside from that, there's a mod that adds histories to character creation, though i wouldn't know where to find it. One thing to keep in mind, is that clan-specific content is minimal at best. I've played almost through with a Nosferatu, and a bit with Tremere, both disappointed me somewhat.
Tremere usually gets a few dialogue lines here and there about how they aren't trusted, and that's about it. You get a new kewl haven, but it has no special functions, and you get it later in the game than the regular one, so no upside there either. Blood magic sounds cool and all, and it does have some spectacular effects that are lots of fun to watch, the problem is staying alive long enough to get to watch them, as you're pretty limp in combat otherwise.
Don't get me wrong, it can be a fun clan to play if you carry a zillion blood packs at all times, and stay out of harms way, but it's still nowhere near as unique as it should be.
Nosferatu are interesting to play, if you walk up to any normal person in the street, you get an instant masquerade breach, which is fun at first, but gets annoying later on. You get a bunch of new responses from people, but again, it's one or two new lines, they're completely superficial, and usually have no impact on the rest of the person's dialogue. Other Nosferatus in the game also have very little to tell you, that they wouldn't tell anyone else. As if the main quest wasn't linear enough, it also treats you the same no matter what clan you are. Such a shame. Nosfs also get a new haven, but it doesn't even have a working TV, and you get it even later than the Tremere one, so that's just more bad news.
Obfuscate only works against weaker enemies, and lags up the game even more than usual, so don't rely on it or anything. I used Animalism and had a blast with it, particularly the spectral wolf and bloodsuckers' communion traits, tons of fun when combined with sneaking. But again, like blood magic, these effects don't hold up against supernatural creatures, and the Hollywood sewers is still the frustrating shithole it's always been.