In any event, there is a bazillion ways you could do urban fantasy without involving vampires. Even if you do involve vampires, there’s tons of ways you could do them without racially segregating them by high school clique.
For example:
A person who dies but is too scared to cross over reanimates their own body as a vampire who, absent the direct emotional ties that fuel ghosts indefinitely, must drain that emotional energy from the living. Joy, anger, fear, awe, inspiration, sexual ecstasy… any emotion will suffice. Some become torturers, bards or muses. A vampire can even retrieve recently deceased souls and revive them as new vampires subservient to the one who animated them. But as one of the evil dead, the vampire’s magical nature is unraveled by things like sunlight and funerary rites.
A person who suffers a near death experience or nightmare passes through the lower planes, however briefly. This one was unlucky enough to bring back a shadow person, who assimilated their soul and turned them into an ageless being who must absorb energy from emotions to sustain their immortality. As a being of the nightmare realm, the incubus can develop thematic magical powers like transforming into a monster of nightmares, conjuring nightmare creatures from the lower planes, or even communing with the dead and raising them to a semblance of life.
A vampire is not a viral curse, but a corpse reanimated by a passing demon. He retains his memories of life, but now hungers for blood and fears the sun. His undead body will live forever if he is careful, and the demon grants magical powers. He cannot turn people into vampires, but makes empty promises to sway familiars into service.
The vampire is the result of infection by alien nanites leftover from an ancient war. The nanites transform human hosts into ageless augmented supersoldiers, even awakening the latent psychic ability of the human brain. Vampires are reliant on drinking blood to get sufficient iron to manufacture nanites, and UV light overexcites the nanites to the point of fatally burning out their host. The nanites cannot overwhelm a healthy immune system, so vampires must drain new hosts until comatose to weaken the immune system enough to allow sufficient replication.
Etc.
As for settings without specifically focusing on vampires…
You could go for a more X-Files route where there are aliens, cryptids, fairies, demons and Illuminati conspiracies competing.
You could go for a more fantastical tone where fantasy races like elves, dwarves and orcs live in the modern world hidden behind glamor.
You could have the magic be public knowledge, ranging from recently revealed to other possibilities…
A full blown alternate history where Tir Na Nog holds a seat on the British Parliament and Dracula is prince consort to Queen Victoria.
A secondary world where a medieval fantasy world underwent an industrial revolution.
You could have a scifi future setting where demons invaded Earth a la Doom, only for the gates of Heaven and Fairyland to release tides of magic that reshape the post-Apocalypse Earth into a fantastical wonderland full of elves, dwarves, orcs, wizards, robots, cyborgs, mutants, etc.
All of those are examples of urban fantasy. The possibilities are endless!