If I go standard roguelike noob route of strong guy with big axe, I get smashed.
See below for such a character which I won with.
Early game can be tough. You have to treat stages as big playgrounds to run around in – which means learning to run away from fights to reconfigure and come back. Zorbus is rather subtly a stealth-heavy game and you have to learn to hit and run and use the environment to your favor. Not sure if they fixed this, but one neat trick was to yoink enemies into the marketplace where they'd get killed off in all the chaos. (Though, rather scarily, there are monsters who can dominate in there.) Learning to run (and how to run) from fights is the #1 tip I'd give, as most deaths result from overcommitting when MOST times you could just leave and come back in a manner that is more to your advantage.
Here's my melee heavy bro:
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Curious. I have indeed used the marketplace of doom trick. It still works. But I feel like the most dangerous moment is when you just enter the floor. You open the first door and you get 3 energy beams and a web thrown at you. You blink away with a potion, but end up in a room surrounded by evil spirits. You run from there and it's wizards again. You try catching them but now they blink away. And the dimension lock items are few and far between. I just always feel like I'm lacking the tools I need. Once I set up a maze of traps before a tough encounter. Fireballs, summons, webs. Fireballs did the customary 0 damage. The summons got chopped in one turn. And I don't think anyone even stepped in the web ones.
I do know I've not been using stealth much. Maybe that's the key. How did you get your stats this high? You start with around 14 in primary stat with 12 in secondary ones (you need both body and motion and at least 12 in spirit or mind to get perks and skills). And the only way to permanently raise attributes are perks of +1, but you can only get +2 to each stat like that. Plus the occasional potions of +1. But in all my dozen or so runs, I've rarely seen more than 2-3 of those per run.