No, because creatures won't ever accept a yield from you.
And it is quite easy to set up NPC's to yield or flee if they start losing.
Here's how yielding works for an NPC or creature. Whenever an NPC takes a hit, or if their weapon breaks or they run out of magicka (or a few other circumstances), the NPC re-evaluates its strategy. This includes deciding to either flee or yield. Current health, weapon status, and more go into both of these decisions. The decision to flee is also based heavily on the NPC's Confidence stat, while the decision to yield is based on the NPC's disposition towards their opponent. If they decide to yield to another NPC or creature a quick check is done to see if the opponent would accept a yield -- that's based on the opponent's disposition towards the yielding NPC or creature, among other things -- and if so, the creature/NPC yields and the opponent stops combat with it.
When yielding to the player character, obviously the "would yield" check can't be done automatically, and so the yielding actor plays a yielding animation (and NPC's say something along the lines of "you have bested me" -- there's a bunch of choices for them). Then the player has the choice of either continuing to whale away on the yielding actor, in which case the actor might choose to flee (or might even start fighting again, since the post-yield attack lowers the actor's disposition towards the player). Or the player can simply stop fighting the yielding actor and combat ends.
The player can yield to an opponent in combat by pressing the "activate" key (spacebar on the PC) with the opponent close enough to activate. This is the same way you initiate conversation when you're not in combat. Anyway, if the opponent would accept the yield, the opponent says something to that effect and then stops fighting the player. If the opponent would NOT accept the yield, the opponent keeps fighting -- and NPC's might sometimes taunt the player. And as I mentioned, creatures will never accept a yield from the player.
Basically yielding all comes down to disposition. If you go up against someone who really hates you, that person is unlikely to attempt to yield or to accept a yield. If that person's confidence is low, he'll flee. But if the confidence is high enough, he'll fight to the death.
It's very configurable on an individual basis through simple modification of stats.