Compared to AOD you get a metric shitton of alchemical reagants and bombs and the like, so compared to AOD use them more liberally.
That said, if you need to exclusively use bombs to fight constructs you'll eventually run out, so maybe use them to get by when your level/build at the moment can't handle it
I've seen this sentiment repeated by a lot of people from the early stages of the game's release, however, I'm playing it atm and have to abandon my first run quite a way into the game as I've completely run out of both Liquid Fire and Bombs & all the reagents needed to make them.
& it was from comments like this that made me comfortable in using them when I did (usually for boss-like encounters or to first-turn an enemy bomber) & I still don't feel like I've been liberal with them, quite the opposite. I've also completely run out of Healing Salves without ever using more than 2 after any fight.
So I'm having to abandon my first game at the first encounter at old town, against the Enforcer. There are two other encounters available at this point, the four Dark Centipedes, also impossible & the three Worms, which are easily beatable but then I can't open the crafting chest anyway & other than that there is no useful loot there anyway.
As I suspected, just like with most bad RPGs, it all basically comes down to fireballs at the end of the day, regardless of "muh military tactics" horseshit.
Or maybe I just picked a particularly difficult first-time build... 8 Charisma Bow Archer, 4 man party, so... low SPs combined with too many people to heal after battle & Bow Archers being a bit crap late game?