Switching with keys feels very sub-par in comparison to seamlessly be able to do this
What is not seamless about using Ctrl/Shift to instantly switch between sneaking and running? And why would you level this particular argument when one of the distinct advantages of mouse/KB is allowing you to seamlessly switch between many different weapons and items, something that typically requires accessing a menu if you were to play with a controller?
It's instant with keys, but not seamless and analog like on a controller where you seamlessly go from sneak,slow walk, walk,run, and you only need the stick.
Keys can be good, i like it for first person shooters when i need to quickly change weapons. but weapons in RPG's is usually just a button press on the controller (typically the digital cross).
Any open world RPG? Elex, all the Risen games, Witcher 3, all the Bethesda ones, all Dark Souls etc.. all the RPG's worth playing basically.
How is holding up a controller with both hands more comfortable than lightly resting your hand on the mouse? What are you doing that you have to twist your wrist?
To use a normal mouse you are twisting your wrist in a unnatural way that can lead to problems. Usually not a problem for younger people and yes there are now pistol-grip mouses, i have one, not really super digging it though.. one or two hands doesn't matter since i'm gaming anyways. Also for RPG's you usually have one hand on the keyboard, unless it's a very simplistic mouse driven game. You can sit in any position too, i personally like to lay down, i see it as a bonus feature
Again, not saying mouse/keyb is worthless, it's decent and it's what i've used for the most of my life, but i've gotta say these last few years i'm beginning to favor the controller more and more, even found you can be really precise with it, almost to the degree of mouse, takes tons and tons of practice though, not something you learn in a week...