For pre-OSX Mac stuff:
Jewels of Arabia: Dreamers
I'm pretty sure there was some Codexer that was talking about playing this some years ago and said it was good.
Pillars of Garendall
Also, if you're going to include Escape Velocity, you might as well include it's sequel Escape Velocity: Override. Though people are apparently [working on bringing it](
https://www.kickstarter.com/projects/cosmicfrontier/cosmic-frontier-override/description) to modern machines.
As for The Odyssey and Odyssey: The Legend of Nemesis, they are indeed unrelated. I believe Jeff Vogel has talked about how the latter (which is supposed to be a somewhat unusual RPG) inspired some of the stuff in his games.
Here's a good blog post going over Jewels of Arabia, Odyssey: Legend of Nemesis, and Cythera, all of which a lot of people seem to have good things to say about.