First off, I played the game through until the (decent, if not providing any closure) ending. Yahtzee was unnecessarily harsh in some aspects (the game is not "overly complex", lulz), but he also had a lot of good points.
The horrible fetch-quests were already mentioned (I just completely ignored them after I got enough $ to get my good armor in chapter 2), but plenty of the storyline quests were annoying fedexes too under the guise of "investigate this" or "research that". If this was indeed discussed 4-5 months ago in some other thread, I humbly ask for forgiveness!
Combat was challenging up to chapter 3-ish, at which point I got enough skill points and signs to kill any enemy I wanted with minimal effort; just an autoattack-fest with occasional igni kiting and using the "fear" bombs + group style when enemies clumped up on me. But then, this is also the case of many other RPGs, if the player "plays their cards right", they usually start to overpower the enemies in mid-late game.
Inventory management was a throwback to the 1990s. I personally didn't mind rearranging my inventory every 30 minutes and making routine trips to the "bank" (except for chapter 3, ugh) to store the excess materials, but really, making a separate reagent bag with unlimited capacity (and reducing the backpack's capacity) wouldn't have hurt the game imo. Oh noes, this probably makes me an RPG-lite Oblivionite! Burn the heretic.
Load times were really, really bad in chapter 2 and 3, but tolerable after/before that. I actually skipped almost all sidequests in chapter 3 because loading the market quarter + autosave took 10-12 MINUTES every time. There was an entire sub-zone in the market square that was only used for a "showdown" sequence and was inaccessible for most of the chapter (but still had to be loaded every time), they could've moved it to another zone completely. This wasn't a problem in other chapters, though.
Yes, I patched to 1.2 and my PC doesn't suck (could use more RAM, but eh).
The 'shades of grey' thing was kind of a red herring (even though I plan to replay the game at one point and joining the squirrels). Both factions were pretty much the "bad guys" (in)directly responsible for many of the bad things happening to Geralt, and of course staying neutral made 'em both want to kill him. Still, at least giving the option to take a side is better than 95% of the ultra-linear "RPG" crap out there.
Originally I thought the "piss someone off and they won't ever talk to you again" thing was a nice touch, except that all it takes for them to forget your actions is to exit and re-enter the building.
-- Z.