One of my favorite PC Role-playing games is Arcanum. What I like about it is that the gender you choose for your character affects the paths open to you as you play. When you first choose your character, choosing male adds one point to your strength and takes one point away from your constitution (the baseline is 6 points in each category). If you choose female, you get one point deducted from your strength but a one point bonus to your constitution. The biological basis of this might be questionable, but the scheme adds to the variety of character-creation.

One of the quests in the game involves gaining entrance into a gentleman's club. In this steam-punk Industrial Revolution world, attitudes are still very sexist. The doorman at the gentleman's club won't let my female elf in. But I have a special letter from the owner. At that point the unhappy doorman allows the lowly female into the club, although he cautions me to make my business quick.​