Been playing this a bit since yesterday, it's been pretty fun so far.
Made a guy who specializes in Guns, Speech and Repair. Repair has been a really useful skill for me. Besides fixing shit and crafting stuff at work benches, I was also able to use it to do random handyman shit like fixing radios and generators for caps, fixed an elevator in one of the Primm hotels that takes you to an otherwise inaccessible area (I think, maybe there's another entrance?), and was able fix a floating eye-bot found in Primm that joined my party. It's not much of a fighter but it can carry around 200 pounds so it's a good pack mule and it gives you a new quest, something to do with Enclave recordings on it. Haven't fooled much with it.
Right now I just finished a quest in Boulder City concerning some NCR troops and Khans. Khans were holding hostages in attempt to escape the city. I was able to use speech to convince them to let the hostages go and in return the NCR would let the Khans leave. He agreed and let them go but when I got back the NCR were planning on attacking the Khans anyway. You can let the NCR go through with it and even join them or try to convince them to honor the deal.
There was another quest where a crazy ghoul had built a religious cult around himself with a bunch of other ghouls and one human, and was planning on using a rocket to launch them to the "great beyond" or some shit. If you question him a bit a reveals that his chief engineer (who is also a brainwashed follower) will not be allowed to join them because he's human and would die from the rocket's radiation. If you tell him this he gets pissed and asks you to help sabotage their rockets in revenge. You can do it, or convince him to let it go and he'll go back to Novac to live there. Anyway, ghouls launch off in their rockets towards...somewhere. There was a computer you can use to alter their flight course but my Science skill wasn't good enough to see what it does.
Favorite gun so far is the powerful bladerunner pistol. Love its reload animation.
Anyway, currently on my way to New Vegas for the first time to find the guy who shot me. Looking forward to seeing how this area has been designed. Recruited a BOS Scribe on the way there, but found her really annoying. Blew her head open and took her power fist and sugar bombs.