It could be the 37565349857th PF campaign setting, but I don't really see how that would work, Sawyer being a 4E-fag and all, so why not make a wholly system-neutral setting book in that case?
TBH the image makes no mention of PoE and features (nothing but) PF and Obsidian prominently, so a CRPG still seem the most likely to me. Plus, if not, why would it be hung between the others?
Anyway, 4e is a fine system for what it is, but it isn't D&D, and either way, while I could just about stomach the rules, the lore-rape committed on Eberron and FR still has me seething. Well, not that I care much about Realmspace at all to begin with other than some fond CRPG memories, but I'm a man of principle.
5e looks like a good D&D system (and for the first time ever it makes sense how the Wizard's and Cleric's spellcasting works), but TBH it's significantly too simplified for me (no skill points!!); feels more like a Basic Dungeons & Dragons in relation to 3e's Advanced Dungeons & Dragons in all but name.
So when it comes to combat-heavy TRPG rulesets, Pathfinder (with some minor adjustments for the sake of consistency) is still just about perfect to me. The setting however... *sigh* the countries of the core region (as well as most of the core deities) are highly varied and for the most part rather interesting, and in many ways they've got their (queer) priorities straight, but it has largely the same issues most other popular generic TRPG fantasy settings have, and it's simply far too young in comparison to still be forgiven those: Human deities largely lacking the theme/feel of being a family or even having any family connections at all, non-human pantheons being severely underdeveloped (Ironically the elves have it worst among the core player races on Golarion despite traditionally being the least bad offender.), East Asian counterpart cultures and deities severely lacking in creativity/effort compared to the pseudo-European core, and part of the Old Egyptian pantheon (roughly the Ennead) being applied wholesale to a desert region without even changing the names*. Plus, it so fugly (ironically enough, the core setting book aside). I can ignore the unnecessarily weird looking and lethally cursed to boot gnomes (largely because I don't give a flying fuck about them and halflings anyway) and even the double atrocity of tall elves with physics-defying eyes, but the generally overly cartoony art style and impractical gear have me almost wanting to stab out my own eyes to escape looking at them.
Actually kinda funny, considering how I also love the TDE and SR rules as well as the overall feel of their settings, but damn, are those two forever bogged down by institutionalized stupidities established in their early days. (Well, SR is pretty fine these days, as long as you ignore the many at best hilarious** names of by now thankfully largely historical (i.e. dead) Japanese characters established during the first two editions. Misused Japanese terms in English speech are believable enough, but as long as they don't retcon away the supposedly Japanese term "kawaruhito", I'm always ready to cringe at it. TDE however... Aventuria's a hopeless case, the main problem being that it's a continent merely the size of Central Europe that has fantasy counterparts to cultures and climates of all of (Early Modern) Europe as well as most of the rest of the Mediterranean and then some (plus a handful of non-human realms), making supposedly huge deserts rather tiny, and confounded by there being a much more unified counterpart to the HRE but with no rival nation of remotely the same size to realistically hold its expansion in check, yet the status quo persists. They fairly recently tried to slowly break it up through infighting and betrayal but eventually chickened out (after a complete staff change).)
Incidentally, I read up on the most popular (pseudo-European fantasy) settings in Japan some months ago, and they make me wanna vomit in their even for Japanese standards astonishingly haphazard, blissfully ignorant construction. (And gods, do I despise Japanese-style floppy elf ears.) I have tolerance for that when there's actual writing (specifically, interesting characters) to make up for it but not otherwise. Plus, the descriptions of the respective rulesets don't exactly have me salivating for them, either, to say the least.
*Either do it or don't, but I can't stand half-assed inconsistency.
**The best example being their counterpart to Emperor Hirohito being called Irohito - which is neither a personal name nor a common noun, but the only way to translate it would be "lecher".
Edit: Well, that's what I get for rambling on forever without checking the new posts. The PF card game doesn't really interest me, like, at all, so turning that into a video game or fifteen would be even less likely to get me fapping, but yeah, really seems like a PF CRPG is on the way (and a PoE TRPG is not), so I'm cautiously optimistic.