I find it excruciatingly hard to play an RPG for longer than 15 minutes if it starts in "ye olde generic village" with all the typical quests and problems it entails, and there were numerous ones I dropped, never to return, just because of that shitty kind of beginning.
THAT FUCKING VILLAGE IN NWN 2
Yep, NWN 2 was one of the games I dropped because of the ye olde generic village start. Two more examples that immediately come to mind are Drakensang and Divinity 2 - fortunately in the latter case I revisited the game at a later point in time and gritted my teeth through that shit, because what follows is great.
I can't explain it, but the generic village start is just overpowering for me. Especially when I first get to spend a decently long time during character creation - but after that, if I'm dropped into Bumfuck, Nowhere, I say 'yeah ok I'll check back later', and never do.