THere were 2 things that really set Wasteland apart from other contemporary RPGs:
1) The adventure game mechanic, IE the Use Skill/Stat on Object mechanic, that allowed you to solve problems and find secrets
2) Gore, violence, dark humor, etc.
These were basically the same things that survived into the Fallout Series and made it the "spiritual successor" to Wasteland. So I am not sure if anything we're going to get here could really be better than classic Fallout, unless they really try to exceed it in other ways.
So really what I'd like to see is super-detailed tactical combat, not something like you have in Fallout, where they try to balance bare-knuckles fighting with .50 cal machineguns and plasma-blasto rifles and so on. I'm talking, Jagged Alliance 2 combat, line of site, interrupts, multiple Z-levels, wounds and lighting that affect performance, different stances, a obsessively accurate projectory and cover system, all of that. This is the only thing that could make me really look forward to the game. If it doesn't have a combat system like this, we might get something AS good as FO1, but it won't be novel at this point, so even fans of FO might find it a bit underwhelming since they've already played a very similar game before.
Agree w/1980s pop and Cold War culture as a background narrative for the game world. Definitely need a Ronald Regan surrogate, as to this day he is what I think of when I hear the phrase "Cold War".
Also needs: scorpitrons, proton axes, crazy old people with anti-tank weapons, radiation cults, desert survival, jeeps, haywire killer robots, medic skills instead of retarded magic potion bullshit, etc.