I actually have insider knowledge on this, no jokes:
1) There will be a new stat called "Power" that will determine how strong your character is. Each level you will get a point to spend and you will spend it on Power because all other stats have been removed to avoid any confusion.
2) Shield blocking will now happen automatically to free up the right mouse button, and left mouse will engage an auto attack mode. Right mouse will pause the game and a special inventory will appear, full of various cheeses. You start with 1000 cheese wheels but if you run out, you can purchase more for Bethesda Cash which is now required for mods too.
3) Left mouse engages auto attacks, right mouse is the cheese selection window, and middle mouse engages shouts which was such a success in Skyrim. The first shout you get will freeze the enemy in a block of ice for around 2 to 3 minutes, but if you double click the middle mouse, you also perform a Fus Ro Duh which will shatter the ice and kill the enemy. So remember, middle mouse twice, and then middle mouse once. Don't worry, the first few hours will be a tutorial.
4) Radiant AI has been improved further so NPCs will now perform even more realistic daily routines. In the morning they will cook as usual, but then they will visit the nearest toilet and sit there for some time, reading the Morrowind Herald. The amount of time they sit here will be determined by the amount of fibre in their diet which is based on nearby food sources. A lot of development time has already gone into this, but more is promised before release. After this they will do their usual chores, sweeping the floor, pretending to make things at the anvil, but now they will also throw horse shoes at a stick or comment on the attractiveness of the ground. This will vary based on the specific ground tile they are standing on.
5) Each town will have a theatre that is similar to what happens in GTA. The player will be able to visit it and see comedy shows where realistic NPCs tell hilarious tales such as the guard who used to be an adventurer but got an arrow in the knee, and, "My cousin is out fighting dragons and what do I get, guard duty!" Players will be able to sit for hours watching these comedy gigs.
6) There will be a crafting system similar to Fallout 4, but steamlined to keep things slick. The player will be able to visit a crafting hut and click the door, and it will automatically upgrade their gear into a better version. The components required will be the original item, and Bethesda Cash.
7) The several types of enemies will be streamlined into one, a Draugawolfspider.
8) All male and female NPC's will be fully voiced, by Robert Downey Jr.