Lore-wise, Troika succeeded in mixing a general framework for neophytes with obscure details about the World of Darkness. By the end of the game, new players will despise Ventrues, fear werewolves and be disgusted by Kindred politics. Seasoned pen and paper players might be surprised to encounter lesser known vampiric bloodlines and other things from forgotten sourcebooks. With this level of detail and the depth of the story, it's a fantastic achievement.

The biggest problem of Bloodlines is that the more you progress, the less the gameplay becomes bearable. Mission zones slowly turn into hack and slash dungeons, giving you no other alternatives than fighting your way through dozens of enemies in extremely small corridors and bland environments (sewers, shady hotels, underground bases). Even worse, the final mission compels you to choose a faction to complete the game and kill one of the main antagonists of the game. The two finals dungeons are a pain in the ass to go through, both ending with a tough-as-nails unskippable boss fight. If your character don't have some good stats in combat skills, the whole thing can turn pretty sour fast.​