From what you've seen, would you call it a definite improvement over the original? (without taking the lack of 2 PCs in the account ofc)
It's still pretty early to say very confidently, but here's my very initial feeling as a huge fan of the original: If you've played the original, want more, but still distinct enough to make a noticeable difference, then there really is no reason why you wouldn't like this game. From what I've seen so far, it's a big improvement in a lot of ways - so much so that I think a lot of people who tried the original, but just couldn't get into it because of its most obvious oddities with its presentation, would be able to finally find enjoyment in Pathologic. Oh, and the translation/writing is particularly polished and excellent in comparison to the original and the HD remaster. This will make a MASSIVE difference for a lot of people.