Tides of Numenera is free to play at this very moment through tomorrow (and on sale for about $20), but the peak concurrent users was a mere 492. More people played freaking Tyranny today even though it's $18.
Well fuck, you are actually right.
Tyranny is a great example of similar and comparably underwhelming game, released in the same time frame, in the same saturated market.
You can find more examples: Baldur's Gate vs Torment, Geneforge vs Avernum. If you have two very similar games, than original and interesting, meaningfull setting seems to have at least -50% sales modifier.
Majority of rpg players are dorks and manchildren. Anything more original and ambitious than generic fantasy and twilight tier character drama puts them off.
It is even more pronounced in pnp market, because if you have one, or two out of four players in the group interested in the setting it still mean no game/ no sale.
Probably Planescape setting was order of magnitude more niche on its market, than P:T game on crpg market.
Interesting statistic was revealed by steam spy guy when D:OS, W2 and PoE were around 500k, but playerbase that owned them all was below 100k.
Basically every year you have newcomers who try the genre only to find it's not for them/ grew up and move on from gaming. Then you have seasoned gamers with little interest in rpgs, who rarely pick one.
Then you have core rpgs player base that is willing to buy few of them every year, it seems to be around 100 - 200k worldwide.
These are the only people for whom original setting is a plus, or at least not an instant turn off.
With a budget below 1M$ and below 100k sales aim, being original can pay off. Here AoD, or Underrail succeded, while latest Avadon sales are very poor.
Because people who play few rpgs every year, but are still not fed up with generic fantasy yet, have multiple offerings with better production values and gameplay these days.
But Geneforge remake wouldn't fare any beter imo, since Avernum remakes were sold mostly to new players.
There is so few games with unique setting, that after all sales and bundles, most of interested players already played Geneforge.
New series from Vogel, but as unique as Geneforge could potentially do better than Avadon 3 does.
Anyway, if developpers pay atention, we won't see unique settings in AA rpgs.