Endgame comparison between PopeAmole II's builds:
Kusanagi - energy weapons, low skill support - only medic skills and Perception
Vlad - shotgunner, high skill support, highest level in party, even if he only had computer science as most worthy skill (?)... or right he also did all Weaponsmithing
Bestia - as her name, almost none skill support (Outdoorsman), did 15000 more damage than anyone else but Shade, pure combat machine - Brawling
Shade - sniper, high skill support (all opening container skills), 10k more damage, 7k less than bestia
Kusanagi did so little damage because she used energy weapons meaning she slacked behind 1/3 game though
Vlad tells us that shotguns are a bit eh compared to sniper rifles or brawling before you get Jackhammer
Also dat difference might be due to Initiative. Bestia sometimes acted twice per turn, sometimes even like Furies from Heroes of M&M V - her portrait were in line twice in a row, 6 attacks one after another... not that anyone needs more than 3 attacks from Brawler in W2 to get rekked, if it's not a boss.
Some minor comments on skills:
Sniper Rifles & Energy weapons. These two have good chance to hit and decent range. EW only improves chance to hit, never jams and never crits, meaning you can pump them with weapon mods, crouch and have 100% chance to hit even with mediocre skill. With Sniper Rifles you can put some headshots quite reliably and also upgrade them with everything.
Meaning, these 2 skills probably can be left at low ranks on 10 INT characters, while you spend SP on something more interesting. They also don't rely on crits much, so get trinkets for +hit, -% crit, if there are trinkets like that.
With EW you want to get to Mezon Cannon ASAP during Arizona play, that can be aquired easily in mutant village if you have a decent sniper rifle and high Safecracking or Computer Science.
Brawling, since 10 points give you 100% chance to crit, if I would make another Brawler I woud go for 4 INT, because it is so important to get to that rank. Plus it's potentially 3 maxed secondary skills, like Outdoorsman or Brute Force.
Alarm Disarming & Mechanical Repair. I had those but they never did much for me. I fixed a well or two and I think that's it. Even in funny interactions like getting money from slot machines, Computer Science can be used instead of Repair. Alarm Disarming was useful one time - to get a recipe from bank, but if you help mayor there, all guards and NPCs from bank vanish, meaning it probably won't matter if you have skill or not.
I would change those for Smart Ass & Kiss Ass cause those are at least fun and I think they are checked a wee bit more often than Hard Ass, or at least checked in more important dialogues.
Field Medic&Surgeon. FM doesn't seem to have any checks in quests, but only checks if you can use medkit or not. Thus this skill should only be upgraded when you collected enough next tier medkits, and NPCs stop selling low tier medkits. So when you're out of pocket and small medkits, but accumulated enough big medkits, invest in it enough to use them. This means that, perhaps, it's usefulness expires after you have 6 ranks in it, since 8 rank medkits only fall as loot at the very endgame.
Surgeon is sometimes checked in quests. At one point of the game tier 1 surgeon kits would vanish, making your surgeon 1 characters obsolete. So I'd say it's either all or nothing skill. I heard Rose has it though so if you go AG, you might not need it.
For just using it in combat, 4 points I believe will be enough for whole game.
Lockpicking&Safecracking. I don't know if it is a RNG based item, but I had an item called Burglar's Mask, I got it in a safe in Rodia. It is a +2LP&SC, -3STR item. Plus books. So ~8 points in these skills may well be enough.
Computer Science. Godly skill because you can turn robots on your side. If you're going to max it to 10, give to char with high AP, spd and initiative.
I think I noticed that, at 10 ranks, you can hack standing 1 tile away, not sure if bug or feature.