Well they said they won't make W2 "ridiculous" (i.e. they won't put funny stuff just for the sake of it being lulzy), so I'm OK with some silliness, because it's integral to the setting, even in Fallout.
The thing is, they will and can put silly stuff in the game (just like in Fallout, like you bros already said), but they won't make the story retarded and lulzy, as well as some of the quests (an example of this is Fallout 3, with its "serious" tone, but utterly lulzy and retarded quests and story).
Don't know why anyone would mind such stuff from Wasteland. Temple of Blood, crazy cultists, crazy mutated creatures... All is well. Just no retardation and too much silly stuff for no reason, like pop culture references from Fallout 2. I dislike stuff like that. It's OK in moderate amounts if they really have to. But still Fallout 2 is one of my favorite games, so all will be forgiven if the game is good.