I wonder if people realise that there's not a lot of reactivity that is actually logical or matters in the game. There are a few strange examples that stand out, one being Scholar tag that is the only tag in the game that has real quests locked behind it (other tags are mostly "Speak a line leading to same outcome: I have this tag!"), but for the most part, even clearing maps of all and any sentient life doesn't affect your game very much. The glowing button near you map seems more like a lie, and neither regional or personal reputation exist or express themselves during the game. For example, if you kill Saheila in 1st act you have a chance to tell about it in 2d act and aggro elven camp on yourself, but you may also not, and still go through generally same Lone Wolfs slaughterhouse (although having Ifan in party delays the inevitable). That's how you can also have both Hero and Villain tags at the same time - do all quests, and then kill everyone on the map
I think one of best examples of companions reacting is the quest about lich in a cellar. You can follow it through until lich basically eats a baby in front of you with all companions being utterly disgusted, say "this is fine", take reward from him and leave him alone. That's it, you're all great and free XP. Companions don't even activate a disapproval penalty.
In one and a half playthroughs, I found it hard to get anything meaningful out of my choices, as everything interesting is inevitably delayed until Act 4.
And don't make me start on Witch in Act 1, or Ryker in Act 2, or Lone Wolf leader there, and all the others, who end up trying to kill you regardless of your actions.