Yes, and I maintain that it is transsexual to inhabit a vessel that is a different gender than your own. It is at the very minimum a form of crossdressing/trasvestitism.
The vessel is a tool through which you interact with that virtual world. In one game you control a woman, in another a gnome, in others a goblin, or an elf or a dwarf or whatever else. In GTA SA you control a black chatacter. In the ballad if gay Tony you control a Dominican one. You start to sound like one of my faculty colleagues who maintained that killing NPCs in videogames is like killing people in real life. Or the mental state of it or something.
So what, when you play other games where you can choose different species to play as, you always play human? For example in BG3.
There's a difference here.
If I want to play Tomb Raider I have no choice but to play as Lara. I wouldn't say that's questionable because I have no choice in the matter. I am 'forced' into playing as a woman if I want to experience the game.
If I choose to make a female character in Elden ring I am making a choice to be a woman. And in my experience the type of people who do this are either transexuals or they make a fetish character they want to fuck. Instead of a power fantasy of a man conquering and pillaging, it's a blow up sex doll in digital form. You're choosing to play as a woman for either of the above reasons and that woman will be acting masculine. She will be performing a male role and often beating up men and being physically superior. Which snowballs into vastly more fetishistic territory for a lot of the people doing it.
People choosing to have a female avatar are weird. Even if it's a woman doing it, it's still weird. Unless a game gives -4 str they don't deserve to be a playable option.