I remember finding a unique sword down a well so there is definitely hand placed, handcrafted loot to be discovered.
Nearly all loot around the world is hand-placed -- even Energy Sword I or Fire Warhammer II or whatever. Only room where it may vary is perhaps enemy drops (do you get a toilet paper or a cup? who knows!). Otherwise all notable loot in containers/locations is the same always, whether its gems or elex potions or gear.
There are 'unique legendary named weapons' that come in two broad categories.
1) Not particularly strong, but the polarity of their stat requirements is reversed -- the Ignis Artifex is the Fire 2handed words that you're referring to. It over-emphasizes DEX over STR. My guess is they assumed this would be an option for people who don't have high STR but do have high DEX but still want to try a weapon like this out. It's damage is pretty low for an actual melee char who will be better off just using a generic fire 2h sword (or any other upgraded 2h).
2) Optimal or near-optimal damage. Mortal Stream (laser rifle), Redeemer (plasma rifle), and Thunderclap (shotgun) are like this. In truth, a fully upgraded double-barrel shotgun is *slightly* stronger than the Thunderclap, but it's by a damage value of like 1-3 where-in it doesn't really matter given that you'd have to spend thousands to upgrade it. These are just best-in-slot for this type of weapon or near-best-in-slot.
agris I thought itemization is *okay*, not great. There's too much redundancy in weapon sub types (3 types of laser rifles, which are basically just -1, and -2 versions of each other). Most weapons follow this trend where there are identical weapons that just have lower damage and lower stat requirements of each other. TBH it's not that different than say Gothic 2 where you have a bajillion 1handed weapons that are stat req/damage done 65/65 70/70 etc. But it *feels* different. I wrote more about this in my long ass rambling "review" of elex a few years ago.
Having said that, gear does represent a much more noticeable leap in power than it did in Gothic or even Risen.
The other thing is that the DOT effects are far more important and often they alone will give you access to areas that you otherwise wouldn't be able to fight through.