On topic of synergies, i didn't go indepth but I feel like INT is best combat stat at least for highest hp bloat difficulty
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you want to do steady, reliable damage, both single target and aoe. Luck also looks fun tho. My favorite gun is just a pistol with +max range scope, favorite stat INT, and does it make sense to give Sneak Shit to everyone including level 10 perk? well I guess it does if you have Explosives, it's just that a sneak specialist with giant missile launcher (and 1 point of strength) didn't feel logical to me
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then again rambo did it, and sabouteurs with explosives do exist eh.