I wish Famine had options to disable container loot removal, period. Disabling locked containers is great, but containers were also handplaced by Obsidian and I wish you could leave those intact.
The equipment repair mechanic is something that needs addressing.
- In vanilla, just slap another weapon/outfit of the same type and you are done.
- JIP LN NVSE Plugin has an option to turn on FO3 repairing, which capped the extent of repairs to your Repair skill. I always enable it.
- Repair Kits requires a consumable repair kit to execute repairs. You can craft it from certain loot (a combination of wrenches, wonderglue, scrap metal, scrap electronics) or buy it ocassionally from vendors.
- Prevent Repair If Not At Workbench from Stewie's Tweaks requires you to simply be at a workbench to perform repairs.
These are the options I've found; I personally use Repair Kits but I'm considering switching to Stewie's Tweaks in my next playthrough and see how that works out. You can also run both at the same time if that's your thing.
For radiation being a joke in New Vegas, I find
RAD - Radiation (is) Actually Dangerous - Overhaul to be a massive improvement. Even small doses of Raditation which wouldn't have made a difference in vanilla New Vegas chip away your max health, handicapping you from the get go.
Jacov Stewie's Tweaks include
Agility Scales Movement Speed as well as
Barter Affects Repair Costs.