From a world building point of view, science fiction can do anything fantasy can, perhaps even more given it's scope.
The ratio of fantasy to space opera RPGs must be something like 100 to 1, if not even worse. Off the top of my head, I can think of only 6 genuine space opera CRPGs, all in two franchises: Mass Effect and Star Wars. No isometric ones to speak of. Add to this maybe one or two closely related genres such as future history/planetary romance/dying Earth, and you can add Torment: Tides of Numenera to that list. Aside from that there are a couple of old pre-1995 things like Albion and Megatraveller, and a couple of upcoming indie games like Stellar Tactics and The New World.
That is still tiny compared to the seemingly hundreds of fantasy RPGs that have been released on PC since the 1980s, and space opera accounts for probably less than half the number of games when compared to post-apocalyptic CRPGs, a smaller literary genre. I'm guessing there are about 20 or so of those, in the form of stuff like Wasteland, Fallout and UnderRail, meaning a tiny sub-genre of science fiction is doing better than the one where alien worlds, social ideas and intelligent species are commonplace.
I see lots of generic fantasy games appearing all the time as smaller releases or indie games. Some of them are shockingly bland distillations of fantasy as a fiction genre, with characters like 'Scottish-accented-Dwarf #375'. To be fair, aside from Planescape Torment, I can't think of many that seem written by someone familiar with Moorcock or Wolfe or Gaiman. Since the RPG is kinda a genre created by geeks for geeks, why are there so few space ones? Why hasn't someone, say, adapted Traveller into a CRPG? Why is there no Star Trek RPG? Or Babylon 5 RPG?
I would love to see something like a space-UnderRail even, but can't InExile or whoever do an isometric Traveller RPG?
Did you check how well those old sci-fi games sold compared to fantasy? I bet if those kinds of RPGs made a lot of money, the mercenaries of the game industry would have been all over them like flies on hot shit.
One of only two sci-fi shows I still enjoy re-watching is Blake's 7. It was amateurish and low budget, but it really had something IMO, and would make a great setting for an RPG.
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