Well, after metal gear solid-ing the depot this mostly just feels like a traps build, since knives can't kill shit. Am I missing something crucial? A knife build appears to use two separate active abilities and a bunch of stacking damage boosts just to, hopefully, at the end of your turn, make one single attack which does as much damage as a regular hit from any other weapon in the game. I'd do more damage taking versatility and no other firearm feats and just shooting things with a pistol.
Max dex, min str, opprtunist/interloper/sprint/dirty kick/expose weakness/cheap shots/fancy footwork so far.
Post-Depot A you have many ways to stack some crazy damage output with knives. You can rack up crit chance - in some cases to well over 75%, but even at say 50% you have so many attacks per turn with knives it's a bonanza. You get unique weapons with special effects (one thing you can do, for example, is to set up Bio infection with the Claw, a fist weapon that a knifer can use well, for huge % increase to damage taken). You can pair Taste for Blood with Free Drones nail bombs or other sources to rack up extra % per hit on bleeding enemies.
That said, a well built knifer on Normal should be doing plenty of damage in Depot A to biological enemies. What kind of knife did you use in Depot A? Are you able to at least knife down a mutie humanoid in a single turn, and if not, what's the roadblock?
The golden rule is that if you're laying 10 traps every fight then your build is severely underpowered for some reason.