A big part in that I figure is that the game is part of an extremely rare subgenre, there's barely any vampire protagonist games ever and even less where the vampirism is not really just a character design element.
Game itself, now that I finished it, hardly justifies it. Being kind, it's a mediocre product without any redeeming qualities besides its subgenre. It's got a case example of how a large map is basically worthless and actually a downright detriment if you fill it with empty space. Huge distances of jogging intersped with trash combat and looting trash from dumpsters because Reid is an ardent tincan recycler is bad enough, but where it really gets terrible is the NPC hub areas after Pembroke Hospital. Huge vast areas of nothing with a handful of NPCs standing or wandering back and forth on their little territory, Landahn Taahn in Vampyr is perhaps the most dead location ever in this sort of game. Not only is it infuriating to slowly plod your way all over the place for every menial thing, it also completely undermines any sort of attempt to establish the world. It's a lifeless, abandoned place that's impossible to care for or even feel disdain for.
What makes the trash combat worse is that Vampyr has the worst kind of subpar combat: The kind that thinks its meh misguided-Souls-clone combat should try to be challenging, without even knowing how to approach that goal. With your very underwhelming assortment of basic stick-slapping, occasional gun, and uninteresting vampire magic, you anemically go through every enemy, dodging the same patterns nonstop and then taking a few stabs at them to gradually lower their huge health bars. Vampyr doesn't even have the good manners like Bloodlines did to just make its combat a shameless powertrip if it can't be good, and it's not like you can't have both good combat and a powetrip at once. The combat is neither visceral enough to be thrilling, nor is it awesome enough to be satisfying. It's a grating, endless mudhole that you just have to deal with, lacking both gameplay and visual flourish. The only emotion to be associated with it is annoyance.
As for the much-touted CnC thing, it's pretty much just a fuck-up there. The game makes the cardinal mistake right off the bat by establishing connection between CnC and game rewards, which with the addition of forced ironman effectively immediately disengages the player from any manner of narrative investment. You'll dig up that walkthrough and stop caring about answering what you think is interesting, because there's the Right answer and the Wrong answer, rather than interesting possible narrative outcomes. This is also added by the fact the dialogue wheel is in full force, giving you next to no information about what you are about to do (just count the number of times the wheel blurb ends in a ! and Reid proceeds to be very calm and polite). Very strange considering these are the developers of Life Is Strange, which had a time-reversal mechanic that actually fluidly integrated savescumming into the narrative and made you interested in what you did because you were always making an informed choice based on what you thought was the interesting thing to do.
Of course, the CnC aspect is largely irrelevant, because the story is shiiiiiiiit. Seriously, the story is worse than VtM: Redemption. And it doesn't even have unintentional hilarity to it. As norm with games of this sort, the dialogue is created in a very wooden, robot-like delivery where one side listens to the other monologue, but there's nothing the Kristof's hilarious line delivery and vocabulary. Aside from the story being usual ancient evil tripe in the end, a particular aspect to its shitness is that it's one of the most poorly paced and rushed stories I've ever seen. You have characters and concepts introduced suddenly and then forgotten about, things bounce here and there without any kind of flow between events, and we have the most bizarre, arbitrary, and sudden romance in gaming history. Johnny Boy and Mah Lady have absolutely no chemistry or even reason to care about each other, the game in fact completely blindsides you by just randomly having it be a thing without any build-up.
I don't even know if it's worth mentioning, but the game naturally does sabotage its own attempts at cartoon moralizing by the fact you kill the vast majority of the local population in trash combat (you can't even call it self-defense since Reid can shoot first too), so getting on your soapbox about sucking the blood of a serial killer is more than slightly silly and disingenuous.
tl;dr review: I wish it'd be Fall already so I could have been playing more Yakuza instead.