Ryujinx crashes periodically and I don't believe it's random. I've noticed patterns with certain actions causing crashes more often than others, like diving off ledges, cutting down trees, and running into those big blue frogs. Most of my crashes were caused from those 3 things. It does it on both OGL and Vulkan, I've already sent them some crash logs.
Outside of the occasional crashes, the game runs fine. Vulkan runs fine on native resolution, but you want OGL for higher resolution, you take way less of a frame rate hit. Vulkan gets less hitches related to building shaders though, so there's benefits for running either.