How many times do you have to try a boss fight to actually get tired of casting 2-3 spells? Maybe I'm immune due to having played Pathfinder: Kingmaker without the buff bot, but this seems absurd to me. I get that Lobos might experience that, but what kind of useless example is that? Do you think anyone here goes for challenges that require hundreds of tries?The issue isn't just duration though it's making the game tedious. Having to switch to your casting weapon, switch spells, switch back to your normal weapon and/or 2 handing. It's a bunch of busy work that makes reentering a boss fight annoying. Using lobos as an example again, he knew he'd be at some bosses a while and he decided not to use buffs because doing them would make it more annoying to fight the boss. I guess you could call it "buff fatigue", but juggling anything more than say golden vow or a weapon resin/enchant gets tedious if you're entering the fight multiple times.
Now I feel like you're just talking about things that just don't exist. I went through a playthrough relying heavily on buffs and never once anything like this occurred. You're making buffing up in this game sound like a complex wave function when, in my experience, it's more like a simple addition.I wish it was that simple but From don't tell you exact numbers. So lets say A and D don't stack, but D is better than A, except when you have C equipped because some buffs buff each others and others don't. Do you're having to juggle talismans and such. And then you run into bosses resistant to your +10 fire damage so your +10 physical is better. But then is it still better with buffs ABCD or are we back to testing 16 times before a boss resisting you? It's a lot of tedium in a game most people enjoy because it doesn't force tedium on you. You just equip your shit and go into the action after the opening cut scene or a boss cut scene.
Of course how much you want to invest into learning the game and optimizing your gameplay is up to you. I don't expect the average player who goes through the game once or twice to pour as much as me into it, but this doesn't makes easy things suddenly incredibly hard.