I've played up to the point of finishing Nashville, what you may call the first dungeon.
Impressions so far:
+ Exploration and setting are very fun, they nailed the awesome feeling from exploring vaults in FO1.
+ There seems to be a good amount of reactivity/c&c.
/ I'm indifferent towards the voice acting. If one could remove the narrator and keep the characters it'd be pretty alright.
/ Loot containers rivaling Expedition Vikings in quantity. But you can just skip them, so I suppose it's ok.
– Lots of bad UI/UX decisions. Hire a proper designer, for fuck's sake.
– Combat is flat and boring. Better than FO admittedly, but not by much. Currently playing at the highest setting with a non-combat character, and I'm still beating every encounter without much thought. I doubt adding another difficulty tier will change anything because the base system is too simple to allow for proper tactics.
+ The silver lining is that, at least so far, I haven't seen any trash-mob encounters.
Despite the flaws, it's a very enjoyable game so far, and I could hardly put it down. Thumbs up.