anus_pounder
Arcane
I want it to be set in Europe during the plague. The gimmick would be that everyone in your party already has the plague and are traveling on a religious pilgrimage because they heard that there is a mystical healer several countries over who can heal them. You would have two separate skill trees: one which builds your skills and stats and another representing the plague that would force you to choose various impediments as the game progresses, so much of character building would be managing the symptoms of the disease (and your character would, theoretically, get weaker the longer you play). Likewise, each character would have a terminal point so NPCs would eventually die (and they'll die sooner if you don't manage their symptoms properly). Of course, Bubonic plague kills relatively quickly so you'd probably have to fictionalize it somewhat, but that wouldn't be too hard to fudge reality on as the plague was a mysterious force back then. Anyhow, if I were writing the game I'd have the healer turn out to be a con artist and thus the entire game would just be one long coming to terms with the inevitability of death.
I'd play the shit out of that game.
Give this man his own game design studio and team.