Telengard
Arcane
For setting, it's not the monsters themselves or the weapons or the level of grit (that's the level of reality in old designer terms). It's how those and everything else are used to evoke time and place. To get to a place other than Lord of the Rings, you need locale names, locale landscape and artwork, locale mythological mini-stories, unique rules design that feeds on the locale mythos, and (just a few) unique monsters who have a non-bog standard look and philosophy of life.
Translation: setting is a sense of style, more than it is anything else. A unique setting is thus something with a unique style, instead of wearing what's popular.
All things fantasy will have lots of similarities with one another, because they are still fantasy. But even though Arthurian legends and Lord of the Rings have lots and lots of similarities, someone could port over Pendragon and make a crpg with its setting, give the look of the game an Arthurian touch, then use all the usual monsters, and it would still feel unique simply because it wouldn't be Lord of the Rings for once.
Translation: setting is a sense of style, more than it is anything else. A unique setting is thus something with a unique style, instead of wearing what's popular.
All things fantasy will have lots of similarities with one another, because they are still fantasy. But even though Arthurian legends and Lord of the Rings have lots and lots of similarities, someone could port over Pendragon and make a crpg with its setting, give the look of the game an Arthurian touch, then use all the usual monsters, and it would still feel unique simply because it wouldn't be Lord of the Rings for once.