Most of DOM's difficulty is bloated HP, actually. There's more enemies, sure, but it's all bloat. Dominating is the difficulty where you play your OP builds without getting bored.
HP bloat is actually welcomed in this case, as run-n-gun high crit free bursts galore and ending most of the fights in 1-2 turns in not much fun after a while.
It's just the beginning of dom that is keeping me from doing a full run - I couldn't finish Newton quest, so I cannot even imagine Depot A.
Newton Quest on DOM: bring 2~3mkII frags and 2 flashbangs, you can cheese the doors to clump all the bugs together and blow them up all at once. They're sensitive to noise, throw a crappy MKI grenade to get their atention, than blow them up with the mkIIs and flash bangs so you don't get killed after throwing the frags. Close doors, wait for cooldowns, repeat. Easy peasy.
Depot A: some sneak, 60 effective hacking and 40 effective lockpick trivializes Depot A. You'll skip most of the fights. The only thing you'll actually need to kill is the mutie with the key to the drill parts.
Early game on DOM is a lot of cheese, but after depot A i usually never use a bear trap again.