New topic: what elements of the setting would you like to see the game touch on?
Paths of Enlightenment for the Sabbat-oriented Clans or just those individuals who keep hold on their Beast by ways different than that of Humanity.
Then there's the various traditions of blood magic that the Kindred use, such as Koldunic sorcery and Abyss Mysticism, for the (Old) Tzimisce and Lasombra respectively. Both these and others should be something more than just powers that the player character could wield for combat purposes.
Blood bonds - those of the usual sort - between a thrall and regnant, and the more unusual, of Kindred trying to reinforce their love by mutual blood bond. Or maybe something like it was between Helena and Prias, I think that one was decently developed, especially towards the end.
The passing of time, changing of ages - similar, but not necessarily the same as it was in Redemption. I don't really expect this game to do it, especially given that we're starting in modern nights as a thin-blood, but maybe for some other VtM game down the line this could be a thing. It would also allow for higher tier of Disciplines' powers available to the player, something which I'd really love to see.
A deeper focus on exploring Kindred lore, something more than just cursory info-dumps by NPCs in a game.
I wouldn't really want to see other splats from WoD too much involved with Vampire, it just wouldn't be handled well, I fear. At least, not from the perspective of a Vampire. Now playing as an Iteration X agent and purging leeches and other reality deviants with your experimental tech would be absolutely fantastic. I'd be all for that. But I doubt Paradox would actually ever make a game that let you play as an Enlightened scientist with a narrative that supported it.