I got stuck in a "Spellcasting Mode" trying to crawl under a log and only managed to get out of it via Trial&Error (Pressing the Number keys puts you in it and the only way to get out of it is pressing R). After trying that for a while I forgot what the key for highlighting items (holding down V instead of just pressing it which enables Eagle vision) was and had to figure that out again. I tried equipping the Tomahawk you pick up right at the beginning and couldn't get it to work, tried clicking on, double-clicking the item in the inventory, tried dragging it over the Paperdoll to the right and it dropped it on the ground instead, pressing different keys etc. and nothing worked. (It was RMB over the item in the inventory to equip).
I somehow got locked out of the inventory screen where the items are to the left and the character portrait to the right while attempting to equip items and couldn't get back to it. (Pressing "C" apparently changes the inventory screen into a Stat screen and only pressing "C" again which isn't displayed anywhere can get you back to the Inventory screen). I tried going to the objective marker for the village and got locked in combat without a clue about how to equip weapons still, luckily the enemy apparently didn't know how to climb ladders, I figured out it was RMB right after this:
I somehow managed to get to Level 2 and up to 4 by killing hostile Injuns spamming LMB, but have no idea how to Lvl Up or how Skills work (Clicking around on anything here does absolutely nothing, I found out after I was already done with the game that it's something that again only works using RMB):
You have to switch between Primary and Secondary weapons using T for Bow and R for Melee for some reason. I completed a Quest about some missing guy and was suddenly teleported to the water halfway across the map mid conversation. Another Quest called "Tradition" that had me "find a treasure" by pressing V to activate "Injun Sense" near where the Quest marker was says "Bring the valuables back", but the Dialogue Option is greyed out:
I made it to some glaciers, I did a Quest where you have to find bear meat and kill something that can best be described as a Minecrawler from Gothic, on my way back it said to talk to Innawanid, but the conversation didn't trigger no matter what I did:
All of that aside from other obvious stuff like a long time to load textures, missing animations while talking, shitty animations while jumping, tough to maneuver just right to be able to hit "E" to talk to people or pick up items, most of the Quests being either Fetch or Kill Quests etc. Not exactly great first impressions.