Today, I've had two friendly NPCs turn hostile towards me. One, because he was in the room when the duration of the control spell on the elemental ran out, and for some reason he decided to side with the elemental. I had to reload and redo the boss fight, because I already sank 8 hours into keeping this particular shitbag alive, why not invest 10 minutes more. In another instance, Minsc decided to kill me because I finished off a knocked out cultist, whom he apparently regarded as a dear friend.
I won't even talk about the halberd jannies keeping you out of half the quest locations. The less is said about restricted areas, the better.
At least you don't fall for killing goblins anymore.