I'd like to see the enemies using airhypos (I think they're called) occasionally, I mean there are so many of the fuckers lying around everywhere you'd think they'd have the brains to use them. The only enemy I've seen use an airhypo is the special forces cyberpsycho on Pacifica pier, and the game seems to think that makes him super difficult. You don't want it too often ofc otherwise fights would drag on too much, but maybe once every fight if someone used it, it would be a pleasant surprise, and add a bit of realism and a teensy bit of challenge.
It's quite jarring when you're the only person in the whole of Night City who seems to have the brains to use these thing that are lying around everywhere, and huff them like there's no tomorrow.
And speaking of huffing them like there's no tomorrow, what happened to CDPR's cool thing of you building up toxicity? That would be a nice thing to add IMHO, given that the gameplay is set up as it is, and is unlikely to change any time soon. You could have the antitoxins be moderately available but rarer than the airhypos. That might balance it out a bit. You even have a biomonitor built into your cyberware, so it would make sense to tell you when you're getting into the yellow, then the red.
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Re. the combat AI, I really do think the game does have proper responsive AI in there somewhere, because it does seem to work perfectly well about a quarter of the time (maybe less, about 1/6 of the time if you're sniping the fools). For example, in both runs I've done at the old petrol station in the Panam quest, the AI has been pretty good, actually quite sneaky.
I think this is probably one problem they'll be able to fix in the not to distant future.